Hammad, H. G. H.
; Mostafa, Amany A.
; Hashem, A. M.
; Oudadesse, H.
; Badr, N. A.
; Habib, S. I.
; Mabrouk, Mostafa
; Mahmoud, A.A.
Bioactivity and Drug Delivering Ability of a Chitosan/46S6 Melted Bioactive Glass Biocomposite Scaffold
Interceram 62 (2013)  444-452
Macroporous chitosan scaffolds (Ch) reinforced by quaternary bioactive
glass with the 46S6 system of 46 mass-% SiO2, 24 mass-% CaO, 24 mass-%
Na2O, 6 mass-% P2O5 prepared by a melting technique (MB) loaded with
ciprofloxacin (Cip) were prepared by a lyophilization technique. Theses porous composite materials were especially designed as both a drug carrier for controlled drug release and a scaffold for bone regeneration. The biodegradation rate and in-vitro mineralization of the prepared scaffolds were performed by soaking the scaffolds in simulated body fluid (SBF). Phase identification, microstructure, porosity, bioactivity, mechanical properties and drug release ability in phosphate buffer solution (PBS) were characterized by XRD, FTIR, mercury porosimeter, SEM coupled with EDS, ICP-OES, a universal testing machine and a UV-spectrophotometer. The addition of bioactive glass resulted in the formation of an apatite layer on the scaffolds surfaces. The fracture toughness (KIc) of Ch is enhanced by incorporation of glass, as the glass content increases the KIc
increase. Incorporation of Cip up to 20 mass-% into Ch/MB scaffolds was successfully achieved during the preparation procedure. The morphology, structure and release behaviour of the loaded scaffolds were found to be highly dependable on the glass content and drug concentrations.
Click page-thumbnail to open full text (pdf):